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Vyfemla (Norethindrone and Ethinyl-Estradiol) is a combination birth control pill that’s taken daily. In addition to preventing pregnancy, it’s also used to regulate menstrual cycles and treat moderate acne. Some brand versions of this medicine are chewable or contain iron to help prevent anemia.
Other brand-name versions of Norethindrone and Ethinyl-Estradiol include Alyacen, Aranelle, Balziva, Briellyn, Cyclafem, Dasetta, Kaitlib FE, Leena, Necon, Nortrel, Nylia, Ortho-novum, Philith, Wera, Wymzya FE and Zenchent.
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How Dr. B treats birth control
Tell us about your condition with a $15 online consultation—no video call necessary.
A medical provider will review your information and prescribe treatment, if appropriate.
Pick up and pay for the medication at the pharmacy of your choice. Or, get it delivered.
About Vyfemla (Norethindrone and Ethinyl Estradiol)
How does it work?
Vyfemla contains forms of progestin and estrogen. These hormones work by inhibiting ovulation (the release of eggs from the ovaries) and thickening cervical mucus. This makes it harder for sperm to reach an egg. They also thin the lining of the uterus so an egg can’t implant as easily.
What symptoms or conditions can it help manage?
- Endometriosis pain and inflammation
- Heavy menstrual bleeding
- Irregular menstrual cycles
- Ovarian cysts
- Painful periods
- Polycystic ovary syndrome (PCOS)
- Premenstrual Syndrome (PMS) symptoms
What forms does it come in?
Vyfemla typically comes in a blister pack with 28 tablets. It’s monophasic, which means the active tablets all contain the same amount of hormones. Each pack has 24 active tablets (containing hormones) and 4 placebo tablets (no hormones). Some brands are chewable while others are swallowed whole.
Vyfemla vs. Norethindrone and Ethinyl-Estradiol
Norethindrone and Ethinyl Estradiol are the active ingredients in this birth control pill. They can also be found in other birth control pills, but other brands might contain slightly different formulations or include other ingredients as well.
How much will it cost?
Dr. B offers online consultations for $15—which is less than most copays. If a birth control prescription is appropriate, your out-of-pocket medication cost will depend on your insurance and where you decide to get your prescription filled. With a drug discount card, prices for Nortrel 1/35-21 (3 21-tablet blister packs) start at $16.23.
* Prices shown with drug discount card applied. Price may differ depending on location.
Nortrel 1/35-21 (3 21-tablet blister packs)*
More Birth Control Prescriptions
Looking for a different medication? Here are some options.
Vyfemla (Norethindrone and Ethinyl Estradiol) prescription FAQ
What are the benefits of taking Vyfemla (Norethindrone and Ethinyl Estradiol)?
- 99% effective at preventing pregnancy
- Lowers the risk of anemia
- Regulates menstrual cycles
- Reduces heavy menstrual bleeding
- Eases menstrual cramps
- Improves acne
- Lessens premenstrual syndrome (PMS) symptoms
- Treats polycystic ovary syndrome (PCOS) symptoms
- Treats endometriosis and uterine fibroids
- Lowers the risk of ovarian, endometrial and uterine cancer
- Reduces the risk of breast and ovarian cyst formation
- Lowers the risk of pelvic inflammatory disease (PID)
Who should not take this medication?
- People with allergies or hypersensitivity to Vyfemla ingredients
- People who are pregnant or breastfeeding
- Those who have had a stroke, heart attack or other heart problems
- Anyone with a history of blood clots
- People with a history of breast cancer
- Those who have undiagnosed vaginal or uterine bleeding
- People with liver disease
- People who are taking hepatitis C medication with Ombitasvir, Paritaprevir, and Ritonavir, with or without Dasabuvir
- Smokers over 35 years old
Tell your healthcare provider about your medical history and any medications you’re using. They’ll let you know if it’s safe to use Vyfemla.
How do you take this medication?
Take one tablet daily. For the best protection against pregnancy, take your pill at the same time every day.
What happens if I miss a dose?
Take the missed tablet as soon as you remember, even if it means taking two pills in one day. Use a backup contraceptive method (like condoms) for the next 7 days. If you miss more than two pills in a row, ask your licensed provider what you should do.
What happens if I take too much?
It’s important to take this medicine as prescribed, or you could experience side effects like nausea. If you’ve taken too much Vyfemla, call your medical provider or local poison control center (800-222-1222) immediately.
Can I get Vyfemla (Norethindrone and Ethinyl Estradiol) online?
Need an online prescription for birth control? Dr. B has you covered. Just fill out a short health questionnaire to start the process. A licensed medical provider will work with you to find a safe and effective form of birth control for your needs.
Medical information reviewed by Dr. Sudip Bose
Sudip Bose, MD is a world-leading emergency medicine physician, combat veteran, professor, and entrepreneur. With a wide variety of experience, Dr. Bose is focused on endeavors with large-scale health and educational impact. He founded The Battle Continues, a nonprofit assisting veterans with healthcare needs. Dr. Bose is also a clinical professor at Texas Tech and University of Illinois College of Medicine. He is a graduate of the honors program at Northwestern University, where he continued his medical school education at The Feinberg School of Medicine.
You might experience side effects while using this medicine, like:
- Breast tenderness
- Changes in your period flow
- Cramps or bloating
- Breast changes
- Spotting or missed periods
If you experience severe side effects like chest pain or heart attack, confusion or dizziness—or other new and worrying symptoms—contact your health provider or pharmacist immediately.