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Bisoprolol-Hydrochlorothiazide helps treat high blood pressure (hypertension). This hypertension pill combines two medicines: a beta blocker and a diuretic. Together, these medicines work to relax blood vessels and remove extra water and salt from the body. Ziac is the brand name.
Please note: At this time, this medication is only prescribed as a refill at Dr. B.
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How Dr. B treats high blood pressure
Tell us about your condition with a $15 online consultation—no video call necessary.
A medical provider will review your information and prescribe treatment, if appropriate.
Pick up and pay for the medication at the pharmacy of your choice. Or, get it delivered.
About Ziac (Bisoprolol-Hydrochlorothiazide)
How does it work?
Ziac contains two drugs that help lower blood pressure. Bisoprolol is a beta-blocker that slows down the heart rate. Hydrochlorothiazide is a diuretic (“water pill”) that helps the body get rid of excess salt and water. Together, decrease the amount of fluid in the blood vessels and reduce the workload on the heart.
What does it treat?
Ziac is used to treat high blood pressure (hypertension). This also lowers the risk of related complications, like heart disease, stroke, heart attack, kidney failure and vision loss.
What forms does it come in?
This hypertension medicine comes as a tablet that’s taken by mouth. Don’t stop taking it, even if you’re feeling better. This could cause a dangerous spike in your blood pressure.
Ziac vs. Bisoprolol-Hydrochlorothiazide
Ziac is a brand name and Bisoprolol-Hydrochlorothiazide is the generic version. Both contain Bisoprolol, a beta-blocker, and Hydrochlorothiazide, a diuretic. Brand drugs can be more expensive, depending on your insurance.
How much will it cost?
Dr. B offers online consultations for $15—which is less than most copays. If a high blood pressure prescription is appropriate, your out-of-pocket medication cost will depend on your insurance and where you decide to get your prescription filled. With a drug discount card, prices for Bisoprolol 10 mg-Hydrochlorothiazide 6.25 mg (30 tablets) start at $9.91.
* Prices shown with drug discount card applied. Price may differ depending on location.
Bisoprolol 10 mg-Hydrochlorothiazide 6.25 mg (30 tablets)*
More High Blood Pressure (Hypertension) Prescription Refills
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Ziac (Bisoprolol-Hydrochlorothiazide) prescription FAQ
What are the benefits of taking Ziac (Bisoprolol-Hydrochlorothiazide)?
- Lowers blood pressure
- Reduces risk of heart attack and stroke
- Prevents heart failure
- Protects kidneys
- Improves blood circulation
- Prevents vision loss from high blood pressure
Who should not take this medication?
- Those who are allergic to Bisoprolol, Hydrochlorothiazide, other beta blockers or other thiazide diuretics
- Individuals with a known allergy to sulfa drugs
- Those who are unable to urinate
- People with diabetes
- Those who have kidney or liver disease
- People with severe circulation problems
- People with pheochromocytoma tumor
- People who have untreated hyperthyroidism
- Those with myasthenia gravis (muscle disorder)
- People who have slow heart rate (bradycardia)
- Those with low blood pressure (hypotension)
- People with severe heart conditions or heart failure
- People with sick sinus syndrome (a heart rhythm problem)
- Those who have second- or third-degree atrioventricular block (a heart rhythm problem)
- People with asthma, other breathing problems or history of serious lung diseases
- Individuals with a history of severe depression or certain mental health conditions
- Those with Raynaud's syndrome (a condition that causes the fingers and toes to become numb and cold)
- Pregnant women, breastfeeding or those planning to become pregnant
If you have any of these conditions—or a history of dehydration—speak with your healthcare provider before starting this medication. Also, talk to your licensed provider about your medical history and any medications you’re taking.
How do you take this medication?
Take Ziac by mouth with or without food, usually once a day. This medicine can make you urinate more often, so try taking it in the morning or early afternoon. This can prevent you from needing to use the bathroom at night.
High blood pressure is a long-term (chronic) condition that can harm your organs. Medications for blood pressure are not a one-time cure. This medicine doesn't provide a complete cure for high blood pressure, so it's important to continue taking it, even if you start feeling better. If you stop taking it suddenly, this could cause dangerous problems, like heart attack or stroke. Follow your medical provider's instructions carefully.
What happens if I miss a dose?
If you miss a dose of your blood pressure medicine, take it as soon as you remember. If it's close to the time for your next dose, skip the missed one. Don’t take extra to catch up.
What happens if I take too much?
Taking too much of your hypertension medicine can lead to serious problems, like very low blood pressure, hypoglycemia (low blood sugar), slow heart rate and electrolyte imbalances.
If you’ve taken too much Ziac, call your health care professional or local poison control center (800-222-1222) immediately.
Can I get Ziac (Bisoprolol-Hydrochlorothiazide) online?
Dr. B offers convenient virtual consultations for hypertension. If you need a refill of your blood pressure medicine, just fill out a short health questionnaire about your medical history. If appropriate, a medical provider will send a prescription to your preferred pharmacy.
Medical information reviewed by Dr. Sudip Bose
Sudip Bose, MD is a world-leading emergency medicine physician, combat veteran, professor, and entrepreneur. With a wide variety of experience, Dr. Bose is focused on endeavors with large-scale health and educational impact. He founded The Battle Continues, a nonprofit assisting veterans with healthcare needs. Dr. Bose is also a clinical professor at Texas Tech and University of Illinois College of Medicine. He is a graduate of the honors program at Northwestern University, where he continued his medical school education at The Feinberg School of Medicine.
Tell your healthcare provider about any side effects you experience, especially if they bother you or don’t get better after a few days of starting this treatment. The most common side effects include:
- Stomach upset
- Sensitivity to the sun
- Muscle cramps
- Mental/mood changes or depression
- Decreased libido
- Erectile dysfunction
Talk to your health provider or get help right away if your symptoms are more serious. This could include trouble breathing, swelling or hives, chest pain or tightness or extreme tiredness.
Don’t drive until you know how this medicine affects you. Be extra careful in the first hours after taking your pill because of the risk of dizziness or lightheadedness.
This medication, along with its component hydrochlorothiazide (HCTZ), can potentially alter serum potassium levels, so it’s important to keep an eye on your potassium levels when taking this medication. It's best to consult a healthcare provider for routine checks. It's a simple step that can help ensure your treatment's effectiveness and safety.
Getting your blood tested regularly is important to monitor your overall health. It's a good idea to have your bloodwork checked, which may include tests for renal function, glucose levels or potassium levels in your blood. These routine checks help ensure you are in good health and catch any potential issues early.