Get a Tri-Luma (Fluocinolone-Hydroquinone-Tretinoin) prescription online

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Tri-Luma topical is the brand name of Fluocinolone-Hydroquinone-Tretinoin, a combination topical medication for melasma. It includes 3 medications:

  • Hydroquinone to lighten skin pigment and block melanin production
  • Tretinoin, a retinoid that helps skin turnover
  • Fluocinolone, a corticosteroid that can minimize swelling or redness
* Prescription treatment requires a virtual medical consultation with a medical provider to determine if a prescription is appropriate.

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How Dr. B treats melasma

Health assessment

Tell us about your condition with a $15 online consultation—no video call necessary.

Provider review

A medical provider will review your information and prescribe treatment, if appropriate.

Get your medication

Pick up and pay for the medication at the pharmacy of your choice. Or, get it delivered.

About Tri-Luma (Fluocinolone-Hydroquinone-Tretinoin)

How does it work?

Tri-Luma is a prescription cream that contains 3 active ingredients: Hydroquinone, Tretinoin and Fluocinolone Acetonide. It reduces the production of melanin (the pigment responsible for skin color), promotes new skin growth and controls inflammation.

What does it treat?

Tri-Luma treats melasma, a skin condition that causes dark patches on the face. Melasma is called “the mask of pregnancy” because it often affects pregnant women.

What forms does it come in?

Tri-Luma is a topical melasma treatment that you apply to the affected areas of your skin. It’s usually applied once per day—talk to your licensed healthcare provider for specific instructions.

Tri-Luma vs. Fluocinolone-Hydroquinone-Tretinoin

They refer to the same medication. Tri-Luma is the brand name for a prescription cream that contains 3 active ingredients: Fluocinolone Acetonide, Hydroquinone and Tretinoin. Fluocinolone-Hydroquinone-Tretinoin is a generic name used to describe the combination of these ingredients.

How much will it cost?

Dr. B offers online consultations for $15—which is less than most copays. If a melasma prescription is appropriate, your out-of-pocket medication cost will depend on your insurance and where you decide to get your prescription filled. With a drug discount card, prices for Tri-Luma 0.01 %-4 %-0.05 % Topical Cream (30 gram tube) start at $258.45.

* Prices shown with drug discount card applied. Price may differ depending on location.

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Starting at

Tri-Luma 0.01 %-4 %-0.05 % Topical Cream (30 gram tube)*

More Melasma Prescription Treatments

Looking for a different medication? Here are some options.

Common Questions

Tri-Luma (Fluocinolone-Hydroquinone-Tretinoin) prescription FAQ

What are the benefits of using Tri-Luma (Fluocinolone-Hydroquinone-Tretinoin)?
  • Treats melasma and dark spots
  • Evens skin tone
  • Reduces irritation
  • Promotes new skin growth
Who should not use this medication?
  • People who are allergic to any of the ingredients in Tri-Luma
  • People who have a history of skin cancer
  • People who have skin infections or open wounds
  • People with a compromised immune system

If you have any of these conditions, speak with your licensed provider before starting this medication.

How do I use this medication?

Apply a thin layer of this medication to the affected areas of your skin as directed by your healthcare provider. Gently rub it in and avoid contact with your eyes, mouth or other sensitive areas.

What happens if I miss a dose?

If you miss a dose, apply this medication when you remember. If it’s almost time for the next dose, skip the missed dose to avoid unwanted side effects.

What happens if I use too much?

Using too much of this melasma medicine can increase your risk of side effects like skin irritation, redness and peeling. Apply only the amount prescribed by your medical provider to avoid any issues.

If you’ve taken too much, contact your healthcare provider or local poison control center (800-222-1222) right away.

Can I get melasma treatment online?

Yes–by completing a convenient $15 Dr. B online consultation! A licensed medical provider will review your information and, if appropriate, send an online prescription or refill to your pharmacy of choice.

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“I love direct contact with patients—it’s why I chose dermatology! With ample time together, I can use my eyes and mind to diagnose their condition, like a sleuth!”

Dr. Alison Gruen
Dr. Alison Gruen, M.D.Dermatology Advisor

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Side Effects

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Not everyone will experience side effects when taking this medication. When they do happen, they’re usually not serious. Potential side effects include:

  • Skin irritation
  • Peeling
  • Burning
  • Itching

If you experience severe side effects like increased sun sensitivity, severe skin irritation or an allergic reaction—or other serious symptoms—contact your health provider or pharmacist right away.

Dr. B articles about melasma