Scopolamine Scopolamine is a transdermal patch used to help prevent nausea and vomiting caused by motion sickness. The medication is an anticholinergic that works by blocking the chemical acetylcholine from attaching to the receptors in the part of the brain that causes nausea and vomiting. Read more about motion sickness.
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How to use this information
This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective or appropriate for you. This information is not individual medical advice and does not substitute for the advice of a medical provider. If you have any questions, go to your patient dashboard and request a callback for complete information about this product and your specific health needs.
Medication name



COMMON BRAND NAME(S): Transderm-Scop

What you should know about Scopolamine
  • This skin patch is used to prevent nausea and vomiting caused by motion sickness or recovery from anesthesia and surgery.
  • This medication works by correcting the imbalance of natural substances (acetylcholine and norepinephrine) that can occur during motion sickness. It also blocks certain signals to the brain that can cause nausea and vomiting.
  • This medication is not recommended for use in children.
How to use Scopolamine
  • Read the Medication Guide provided by your pharmacist before you start using Scopolamine and each time you get a refill. If you have any questions, ask your medical provider or pharmacist.
  • Peel off the clear backing from the patch and apply it to a clean, dry, hairless area of the skin behind the ear. Press firmly for at least 30 seconds to make sure the patch sticks well, especially around the edges. The patch will slowly release the medication into your body over 3 days. Do not use the patch if it is broken, cut or damaged.
  • If you are using the patch to prevent nausea and vomiting from motion sickness, apply the patch as directed by your medical provider, usually at least 4 hours before the activity that causes motion sickness. Replace the patch every 3 days until it is no longer needed.
  • If the patch comes off or needs to be replaced, throw away the old patch and place a new one behind the other ear on a clean, dry, hairless area. Use only one patch at a time. When throwing away the old patch, fold it in half with the sticky side together and throw it away in the trash away from children and pets.
  • This medication can cause temporary blurred vision and widened pupils if it comes in contact with the eyes. Always wash your hands thoroughly with soap and water after handling the patch. Also wash the area behind the ear where the patch was removed.
  • After stopping this medication, you may experience dizziness, loss of balance, nausea or vomiting, headache, muscle weakness or slow heartbeat. If these effects occur, they usually appear 24 hours or more after your last dose — a result of your body adjusting to being off the medication. Report any such reactions to your medical provider right away.
  • Tell your medical provider if your condition lasts or gets worse.
Potential side effects
  • Blurred vision and widened pupils may occur as your body adjusts to the medication. Dry mouth, drowsiness, dizziness, decreased sweating, constipation and mild itching or redness on the application site may also occur. If any of these effects last or get worse, tell your medical provider or pharmacist right away.
  • To relieve dry mouth, suck sugarless hard candy or ice chips, chew sugarless gum, drink water or use a saliva substitute.
  • Remember that this medication has been prescribed because your medical provider has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not experience serious side effects.
  • Remove the patch and tell your medical provider right away if you experience any serious side effects, including:

    • Mental/mood changes like confusion or agitation
    • Difficulty urinating
    • Fast or irregular heartbeat
  • Remove the patch and get medical help right away if you experience any very serious side effects, including:

    • Eye pain, swelling or redness
    • Vision changes, such as seeing rainbows around lights at night
    • Seizures
  • A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

    • Rash
    • Itching or swelling, especially of the face/tongue/throat
    • Severe dizziness
    • Trouble breathing
  • This is not a complete list of possible side effects. If you notice other effects not listed above, request a callback for medical advice. You may also report side effects to the FDA at 1-800-FDA-1088 or at

Precautions to be aware of
  • Before using Scopolamine, tell your medical provider or pharmacist if you are allergic to it, other belladonna alkaloids (such as Atropine) or if you have any other allergies.
  • This product may contain inactive ingredients, which can cause allergic reactions or other problems. Go to your patient dashboard and request a callback for more details.
  • Before using this medication, tell your medical provider or pharmacist your medical history, especially of:

    • Breathing problems, such as asthma or emphysema
    • Personal or family history of glaucoma (angle-closure type)
    • Heart disease
    • High blood pressure
    • Seizures
    • Stomach, intestine or esophagus problems, such as ulcers, blockage or GERD or hiatal hernia or ulcerative colitis
    • Overactive thyroid (hyperthyroidism)
    • Difficulty urinating, for example due to enlarged prostate
    • Mental or mood disorders, such as psychosis, anxiety or depression
    • Kidney disease
    • Liver disease
    • Myasthenia gravis
    • Uncontrolled pain
    • Parkinson’s disease
  • This drug may make you dizzy, drowsy or blur your vision. Alcohol or marijuana (cannabis) can exacerbate the effect. Do not drive, use machinery, participate in underwater activities or do anything that requires alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your medical provider if you are using marijuana.
  • Before having surgery, tell your doctor or dentist about all the products you use, including prescription drugs, nonprescription drugs and herbal products.
  • Before having an MRI test, tell testing personnel that you are using this patch. Some patches may contain metals that can cause serious burns during an MRI. Ask your medical provider whether you will need to remove your patch before the test and apply a new patch afterward, and how to do so properly.
  • This medication may cause you to sweat less, making heat stroke more likely. Avoid activities that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink plenty of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you experience:

    • A fever that does not go away
    • Mental or mood changes
    • Headache
    • Dizziness
  • Older adults may be more sensitive to the side effects of this drug, especially dizziness and drowsiness.
  • During pregnancy, this medication should be used only when there is a clear need. Discuss the risks and benefits with your medical provider.
  • This medication passes into breast milk. Consult your medical provider before breastfeeding.
Drug interactions
  • Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.
  • This mediication may interaction with:

    • Oxybutynin (Oxytrol, Ditropan XL)
    • Tolterodine (Detrol, Detrol LA)
    • Darifenacin (Enablex)
  • Keep a list of all the products you use — including prescription/nonprescription drugs and herbal products — and share it with your medical provider and pharmacist.
  • Do not start, stop or change the dosage of any medicines without your medical provider's approval.
  • Potassium tablets/capsules and Pramlintide may interact with this drug.
  • Tell your medical provider or pharmacist if you are using other products that cause drowsiness, including:

    • Alcohol
    • Marijuana (cannabis)
    • Antihistamines, such as Cetirizine and Diphenhydramine
    • Drugs for sleep or anxiety, such as Alprazolam, Diazepam, Unisom and Zolpidem
    • Muscle relaxants
    • Opioid pain relievers like Codeine
  • Check the labels on all your medicines — including allergy and cough-and-cold products — as they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
  • This medication may interfere with certain laboratory tests — including the gastric secretion test — and cause false test results. Make sure laboratory personnel and all your medical providers know you use this drug.
What to do in the event of an overdose
  • Symptoms of overdose may include:

    • Severe drowsiness
    • Mental or mood changes like confusion or hallucinations
    • Fast or irregular heartbeat
    • Seizures
    • Hot or dry skin
  • This medication patch may be harmful if chewed or swallowed.
  • If someone has overdosed, remove the patch if possible.
  • For serious symptoms, such as passing out or trouble breathing, call 911. If symptoms from taking this medication are less severe, call your local poison control center at 1-800-222-1222 right away.
Additional notes

Do not share this medication with others.

What to do if you miss a dose

If you forget to replace a patch at the scheduled time, replace it as soon as you remember. Do not use more than one patch at a time.

How to store this medication
  • Store at room temperature. Do not store in the bathroom.
  • Keep all medications away from children and pets.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more information.
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