Quinapril Accupril—the brand version of Quinapril—is a tablet used to treat hypertension. The medication improves blood pressure within 2 weeks, and protects kidney function. Accupril belongs to a class of drugs known as angiotensin converting enzyme (ACE) inhibitors, and works by relaxing blood vessels. Read more about hypertension.
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How to use this information
This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective or appropriate for you. This information is not individual medical advice and does not substitute for the advice of a medical provider. If you have any questions, go to your patient dashboard and request a callback for complete information about this product and your specific health needs.
Medication name




Warnings to be aware of
  • Quinapril can cause serious and possibly fatal harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication.
  • Consult your medical provider for more details and to discuss the use of reliable forms of birth control while taking this medication.
  • If you are planning pregnancy, become pregnant or think you may be pregnant, tell your medical provider right away.
What you should know about Quinapril
  • Quinapril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
  • This medication is also used to treat heart failure.
  • Quinapril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily.
How to take Quinapril
  • Read the Patient Information Leaflet if available from your pharmacist before you start taking Quinapril and each time you get a refill. If you have any questions, ask your medical provider or pharmacist.
  • Take this medication by mouth with or without food as directed by your medical provider, usually once or twice a day. High fat meals may decrease the absorption of this medication.
  • To reduce your risk of side effects, your medical provider may direct you to start this medication at a low dose and gradually increase your dose. Follow your medical provider's instructions carefully.
  • The dosage is based on your medical condition and response to treatment.
  • Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
  • For the treatment of high blood pressure, it may take 1 to 2 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months.
  • This product contains magnesium, which may interfere with the absorption of some medications. See the “Drug interactions” section and consult your pharmacist for more information.
  • Tell your medical provider if your condition does not get better or if it gets worse—for example, your blood pressure readings remain high or increase.
Potential side effects
  • Dizziness, lightheadedness or tiredness may occur as your body adjusts to the medication. Dry cough, nausea or vomiting may also occur. If any of these effects last or get worse, tell your medical provider or pharmacist right away.
  • Bone marrow suppression, alternation in blood counts. Seek medical care if you have bleeding, bruising, frequent infections, pale skin.
  • Angioedema is a potential side effect. Symptoms include swelling of the lips, tongue, throat or neck. This is not considered an allergic reaction and can occur any time during treatment. This swelling can compromise the airway and be life threatening. Black patients and patients with a personal or family history of angioedema are at higher risk. If you believe you may be at higher risk, discuss alternative treatment options with your medical provider.
  • Remember that this medication has been prescribed because your medical provider has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not experience serious side effects.
  • Tell your medical provider right away if you have any serious side effects, including symptoms of a high potassium blood level (such as muscle weakness or slow/irregular heartbeat) or fainting.
  • Although Quinapril may be used to prevent kidney problems or treat people who have kidney problems, it may also cause or worsen serious kidney problems in rare cases. Your medical provider will check your kidney function while you are taking Quinapril. Tell your medical provider right away if you have any signs of kidney problems, such as a change in amount of urine.
  • In rare cases, this drug may cause serious and possibly fatal liver disease. Get medical help right away if you have any symptoms of liver damage, such as:

    • Nausea or vomiting that doesn't stop
    • Loss of appetite
    • Stomach or abdominal pain
    • Yellowing eyes or skin
    • Dark urine
  • A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

    • Rash
    • Itching or swelling, especially of the face/tongue/throat
    • Severe dizziness
    • Trouble breathing 
  • This is not a complete list of possible side effects. If you notice other effects not listed above, request a callback for medical advice. You may also report side effects to the FDA at 1-800-FDA-1088 or at

Precautions to be aware of
  • Before taking Quinapril, tell your medical provider or pharmacist if you are allergic to it, other ACE inhibitors like Benazepril or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Go to your patient dashboard to request a medical provider callback for more details.
  • Before using this medication, tell your medical provider or pharmacist your medical history, especially of:

    • History of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema)
    • Blood filtering procedures, such as LDL apheresis or dialysis
    • High levels of potassium in the blood
    • Liver disease
  • This drug may make you dizzy, which can be exacerbated by alcohol or marijuana (cannabis). Do not drive, use machinery or do anything that requires alertness until you can do it safely. Limit alcoholic beverages. Talk to your medical provider if you are using marijuana.
  • Too much sweating, diarrhea or vomiting may cause dehydration and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your medical provider. Be sure to drink enough fluids to prevent dehydration unless your medical provider directs you otherwise.
  • In rare cases, some people, especially those who already have severe heart disease, may develop worsening chest pain, a heart attack, stroke, blood clots or arrhythmias after starting this medication or increasing the dose. Get medical help right away if you experience chest pain, jaw/left arm pain, shortness of breath or unusual sweating, weakness or difficulty speaking.
  • This product may cause aortic stenosis.
  • This product may cause hypertrophic cardiomyopathy.
  • Before having surgery, tell your doctor or dentist about all the products you use, including prescription drugs, nonprescription drugs and herbal products.
  • This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your medical provider or pharmacist.
  • Older adults may be more sensitive to the side effects of this drug, including dizziness and increases in potassium level.
  • Tell your medical provider if you are pregnant or plan to become pregnant. You should not become pregnant while using Quinapril, as it may harm an unborn baby. If you become pregnant, talk to your medical provider right away about the risks and benefits of this medication. Consult your medical provider for more details (see also the “Warnings to be aware of” section).
  • This medication passes into breast milk. Consult your medical provider before breastfeeding.
Drug interactions (see also “Precautions to be aware of” section)
  • Some formulations may contain lactose.
  • Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.
  • Keep a list of all the products you use—including prescription/nonprescription drugs and herbal products—and share it with your medical provider and pharmacist. 
  • Do not start, stop or change the dosage of any medicines without your medical provider's approval.
  • Some products that may interact with this drug include:

    • Aliskiren
    • Allopurinol
    • Gold injections
    • Lithium and certain other antidepressants and antipsychotic medications
    • Sacubitril
    • Certain drugs that weaken the immune system/increase the risk of infection, such as Everolimus and Sirolimus
    • Drugs that may increase the level of potassium in the blood (such as ARBs including Losartan and Valsartan, certain antibiotics such as Bactrim or birth control pills containing Drospirenone)
  • This product contains magnesium, which can interfere with your body's ability to absorb certain drugs—especially if you take them around the same time. These drugs include:

    • Quinolone antibiotics (Ciprofloxacin, Levofloxacin)
    • Tetracycline antibiotics (Doxycycline, Minocycline)
    • Thyroid medications (Levothyroxine)
    • Drugs for osteoporosis (bisphosphonates such as Alendronate)

    This is not a complete list. Ask your medical provider or pharmacist how long to wait between doses and when you should take your medications.

  • Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely—especially cough-and-cold products, diet aids or NSAIDs such as Ibuprofen or Naproxen.
  • A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking Quinapril. Make sure all your medical providers know which medicines you are using.
What to do in the event of an overdose

Symptoms of overdose may include severe dizziness or  fainting.

If someone has overdosed and has serious symptoms—such as passing out or trouble breathing—call 911. If symptoms from taking this medication are less severe, call your local poison control center at 1-800-222-1222 right away.

Additional notes
  • Do not share this medication with others.
  • Lifestyle changes that may help this medication work better include exercising, stopping smoking and eating a low-cholesterol/low-fat diet. Consult your medical provider for more details.
  • Lab and/or medical tests like kidney function and potassium levels should be done while you are taking this medication. Keep all medical and lab appointments. Consult your medical provider for more details.
  • Check your blood pressure and pulse (heart rate) regularly while taking this medication. Learn how to check your own blood pressure and pulse at home, and share the results with your medical provider.
What to do if you miss a dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

How to store this medication
  • Store at room temperature away from light and moisture. Do not store in the bathroom.
  • Keep all medications away from children and pets.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more information.
Treatment for
Generic Name
Drug Class
ACE inhibitor

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