Minocycline Zilxi is a topical antibiotic foam commonly used to treat symptoms of severe acne and rosacea, including red bumps and pimples. Read more about rosacea.
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How to use this information
This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective or appropriate for you. This information is not individual medical advice and does not substitute for the advice of a medical provider. If you have any questions, go to your patient dashboard and request a callback for complete information about this product and your specific health needs.
Medication name




What you should know about Minocycline
  • This medication is used to treat acne or rosacea. However, it is not used to treat skin infections. 
  • Minocycline belongs to a class of drugs known as tetracycline antibiotics. 
  • It helps decrease pimples and red bumps that occur with acne or rosacea.
How to use Minocycline
  • Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist before you start using Minocycline foam and each time you get a refill. If you have any questions, go to your patient dashboard and request a medical provider callback.
  • Apply this product as directed by your medical provider, usually once daily, at least 1 hour before bedtime. Do not bathe, shower or swim for at least 1 hour after application.
  • Before first use, allow the container to warm to room temperature. Do not warm up this medication any other way, like heating in the microwave or placing in hot water. Wash your face gently with mild cleanser, rinse with water and pat dry. Shake the container well before each use. Remove the cap, then press the top of the can to dispense a small amount of foam (about the size of a cherry) onto your fingertips. 
  • If you are using this medication to treat rosacea, apply and gently rub the foam over your entire face. 
  • If you are using this medication to treat acne, apply and gently rub the foam into the affected area(s) on your face. 
  • If you also have acne on other parts of your body—like your neck, shoulders, arms, back or chest—apply the foam to these areas as well.
  • Wash your hands after applying this medication. This product may stain fabric.
  • This medication is for use on the skin only. To avoid irritation, do not let this medication come into contact with your eyes, inside your nose or mouth or any broken skin, such as cuts, scrapes or rashes. If you do get the medication in those areas, flush the area with cool water.
  • This product is flammable. Avoid fire, flame and smoking during and right after applying this medication.
  • Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.
  • Tell your medical provider if your condition does not get better or if it gets worse.
Potential side effects
  • Skin redness, dryness or itching may occur. Skin darkening that may be due to acne can also occur. If any of these effects last or get worse, tell your medical provider or pharmacist promptly.
  • Remember that this medication has been prescribed because your medical provider has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not experience serious side effects.
  • Although these effects are unlikely when this medication is applied to the skin, serious side effects have occurred in rare cases when Minocycline is taken by mouth. Tell your medical provider right away if you have any serious side effects, including:

    • Joint stiffness, pain or swelling
    • Signs of kidney problems, such as change in amount of urine
    • Signs of liver problems, such as loss of appetite, stomach or abdominal pain, yellowing eyes or skin or dark urine
    • Discoloration of skin, scars, lips or gums
    • Yellow-gray-brown tooth discoloration
  • In rare cases, this medication may cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped.
  • Tell your medical provider right away if you develop diarrhea that doesn't stop, abdominal or stomach pain/cramping or blood/mucus in your stool. If you have these symptoms, do not use anti-diarrhea or opioid products, which may worsen symptoms.
  • This medication may sometimes cause oral thrush or a new yeast infection. Contact your medical provider if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.   
  • In rare cases, Minocycline may cause a serious increase in pressure inside the skull, or intracranial hypertension (IH). The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. If IH develops, it usually goes away after Minocycline is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you experience:

    • A headache that is severe or doesn't go away
    • Vision changes, such as blurred/double vision, decreased vision or sudden blindness
    • Nausea/vomiting that doesn't stop
  • A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

    • Fever
    • New or worsening lymph node swelling
    • Rash
    • Itching or swelling, especially of the face/tongue/throat
    • Severe dizziness
    • Trouble breathing
  • This is not a complete list of possible side effects. If you notice other effects not listed above, request a callback for medical advice. You may also report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

Precautions to be aware of
  • Before using Minocycline foam, tell your medical provider or pharmacist if you are allergic to it or other tetracyclines (such as Doxycycline), or if you have any other allergies. 
  • This product may contain inactive ingredients, which can cause allergic reactions or other problems. Go to your patient dashboard and request a medical provider callback for more details.
  • Before using this medication, tell your medical provider or pharmacist your medical history.
  • Minocycline foam may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your medical provider right away if you get sunburned or experience skin blisters or redness.
  • This drug, when taken by mouth, can make you dizzy. Alcohol or marijuana (cannabis) can exacerbate the effect. Do not drive, use machinery or do anything that requires alertness until you can do it safely. Limit alcoholic beverages. Talk to your medical provider if you are using marijuana.
  • Before having surgery, tell your medical provider or dentist about all the products you use, including prescription drugs, nonprescription drugs and herbal products.
  • Children younger than 8 may be more sensitive to the side effects of Minocycline, especially tooth discoloration. Tooth discoloration has also occurred in older children and in young adults. Discuss the risks and benefits of this medication with the medical provider.
  • During pregnancy, this medication should be used only when there is a clear need. Discuss the risks and benefits with your medical provider.
  • It is unknown if Minocycline foam passes into breast milk. Consult your medical provider before breastfeeding.
Drug interactions
  • Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.
  • Keep a list of all the products you use—including prescription/nonprescription drugs and herbal products—and share it with your medical provider and pharmacist. 
  • Do not start, stop or change the dosage of any medicines without your medical provider's approval.  
  • This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your medical providers know you use this drug.
What to do in the event of an overdose

If someone has overdosed and has serious symptoms—such as passing out or trouble breathing—call 911. If symptoms from taking this medication are less severe, call your local poison control center at 1-800-222-1222 right away. This medicine may be harmful if swallowed.

Additional notes

Do not share this medication with others.

What to do if you miss a dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

How to store this medication
  • Store at room temperature away from light and moisture. Do not store in the refrigerator. 
  • Avoid fire, flame or smoking since this product is flammable. Do not puncture or burn the container. Do not expose to high heat. 
  • After the container is opened, throw away any unused medication after 90 days. Keep all medications away from children and pets.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more information.
Treatment for
Generic Name
Drug Class
Tetracycline antibiotic

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